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Image Search Results
Journal: Cell Death & Disease
Article Title: USP14 and UCHL5 synergistically deubiquitinate PKCα and translocate NF-κB to promote the progression of anaplastic thyroid cancer
doi: 10.1038/s41419-025-07890-9
Figure Lengend Snippet: A Expression levels of USP14 and UCHL5 in healthy thyroid and ATC tissues using the GEO database ( GSE33630 ). B IHC staining to evaluate the expression of USP14 and UCHL5 in normal thyroid, PTC, and ATC tissues. Scale bar, 100 μm. C Western blotting was used to detect USP14 and UCHL5 expression in one normal thyroid cell line (Nthy-ori3-1), two PTC cell lines (TPC-1, BCPAP), and six ATC cell lines (ARO, CAL62, KHM5M, 8505 C, 8305 C, and C643). D The qRT-PCR was used to detect the mRNA expression of USP14 and UCHL5 in normal thyroid, PTC and ATC cell lines. The experiment was repeated three times. E Correlation of USP14 and UCHL5 expression was analyzed by GEPIA2. F , G Kaplan-Meier plotter survival analysis illustrating the impact of USP14 and UCHL5 expression levels on the survival rates of thyroid cancer patients.
Article Snippet: The
Techniques: Expressing, Immunohistochemistry, Western Blot, Quantitative RT-PCR